DRD3 Gene Summary [Human]
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DRD3 |
| Official Name | dopamine receptor D3 [Source:HGNC Symbol;Acc:HGNC:3024] |
| Ensembl ID | ENSG00000151577 |
| Bio databases IDs | |
| Aliases | dopamine receptor D3 |
| Synonyms | D3DR, D3R, D3 receptor, dopamine D3, Dopamine d3 receptor, dopamine receptor D3, ETM1, FET1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DRD3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- intracellular loop
- G-protein-coupled receptor binding
- protein domain specific binding
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- dopamine D2 receptor-like receptor
- third intracellular loop
- cytoplasmic domain
- cytoplasmic loop
- dopamine receptor
- intracellular domain
- 7 transmembrane receptor (rhodopsin family)
Pathways
Biological processes and signaling networks where the DRD3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- childhood malnutrition
- infection
- diabetes mellitus
- renal failure
- end stage renal disease
- heart failure
- cardiovascular disorder
- Tourette syndrome
- migraine with aura
role in cell
- quantity
- proliferation
- activation
- phosphorylation in
- migration
- apoptosis
- cell viability
- differentiation
- adhesion
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microsomal fraction
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- cell surface
- apical compartment
- perinuclear region
- outer membranes
- cellular membrane
- vesicles
- cytosol
- apical membrane
- synaptic membrane
- synapse
- pedicels
- endocytotic vesicle
- membrane rafts
- brush border
- cellular protrusions
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DRD3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of adenylate cyclase activity
- adenylate cyclase-activating dopamine receptor signaling pathway
- dopamine metabolic process
- acid secretion
- positive regulation of dopamine receptor signaling pathway
- adenylate cyclase-inhibiting dopamine receptor signaling pathway
- regulation of potassium ion transport
- visual learning
- positive regulation of mitosis
- response to xenobiotic stimulus
- learning
- negative regulation of oligodendrocyte differentiation
- learning or memory
- response to ethanol
- circadian regulation of gene expression
- synaptic transmission, dopaminergic
- locomotory behavior
- behavioral response to cocaine
- regulation of dopamine uptake involved in synaptic transmission
- negative regulation of synaptic transmission, glutamatergic
- positive regulation of cytokinesis
- social behavior
- regulation of dopamine secretion
- prepulse inhibition
- G-protein coupled receptor signaling pathway
- negative regulation of protein secretion
- response to cocaine
- reduction of cytosolic calcium ion concentration
- negative regulation of blood pressure
- G-protein coupled receptor internalization
- response to morphine
- positive regulation of MAPK cascade
- phospholipase C-activating dopamine receptor signaling pathway
- cellular calcium ion homeostasis
- musculoskeletal movement, spinal reflex action
- arachidonic acid secretion
- adenylate cyclase-activating adrenergic receptor signaling pathway
- response to histamine
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- dopamine receptor activity, coupled via Gi/Go