FCGR1A Gene Summary [Human]
This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FCGR1A |
| Official Name | Fc fragment of IgG receptor Ia [Source:HGNC Symbol;Acc:HGNC:3613] |
| Ensembl ID | ENSG00000150337 |
| Bio databases IDs | |
| Aliases | Fc fragment of IgG receptor Ia, Fc gamma receptor Ia, Fc gamma RI |
| Synonyms | CD64, CD64A, FCG1, Fc Gamma R1, Fc gamma receptor 1A, Fc gamma receptor Ia, FC gamma RI, FCGR1, Fcgr1b, Fc receptor, IgG, high affinity I, FCRI, Fc γ R1, Fc γ receptor 1A, Fc γ receptor Ia, FC γ RI, IGFR1, IGG FC receptor I, IGGHAFC |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FCGR1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoglobulin domain
- ectodomain
- G-protein-coupled receptor binding
- IgG receptor
- high affinity IgG receptor
- protein binding
- Fc domain
- phosphorylation site
- IgG binding
- cytoplasmic domain
- Immunoglobulin like
- cytosolic tail domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the FCGR1A gene in human plays a role, providing insight into its function and relevance in health or disease.
- Dendritic Cell Maturation
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Glucocorticoid Receptor Signaling
- IL-12 Signaling and Production in Macrophages
- Parkinson's Signaling Pathway
- Phagosome Formation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Regulation of the Immune Response
- Role of PKR in Interferon Induction and Antiviral Response
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- aortic valve calcification
- schizophrenia
- HIV infection
- infection
- acquired immunodeficiency syndrome
- Alzheimer disease
- peripheral motor neuropathy
- diabetes mellitus
- cytomegalovirus infection
- hypogammaglobulinemia
role in cell
- apoptosis
- expression in
- phosphorylation in
- activation in
- endocytosis by
- activation
- survival
- cytotoxicity
- replication in
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endocytic vesicle membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FCGR1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- Fc-gamma receptor signaling pathway
- cell surface receptor signaling pathway
- receptor-mediated endocytosis
- defense response to bacterium
- phagocytosis, recognition
- positive regulation of type IIa hypersensitivity
- immune response
- phagocytosis, engulfment
- antigen processing and presentation of exogenous peptide antigen via MHC class I
- antibody-dependent cellular cytotoxicity
- innate immune response
- positive regulation of type III hypersensitivity
- positive regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- clathrin-coated endocytic vesicle membrane
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- high affinity IgG receptor activity
- IgG receptor activity
- IgG binding