CELF3 Gene Summary [Human]
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
Details
| Type | Protein Coding |
| Official Symbol | CELF3 |
| Official Name | CUGBP Elav-like family member 3 [Source:HGNC Symbol;Acc:HGNC:11967] |
| Ensembl ID | ENSG00000159409 |
| Bio databases IDs | |
| Aliases | CUGBP Elav-like family member 3, expanded repeat domain, CAG/CTG 4, CAG repeat domain, CUG-BP and ETR-3 like factor 3 |
| Synonyms | 4930415M08Rik, BRUNOL1, CAGH4, CUGBP Elav-like family member 3, CUGBP, Elav-like family member 3, ERDA4, ETR-1, RGD1563168, TNRC4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CELF3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ELAV/HuD family splicing factor
- snRNA binding
- RNA recognition motif (RRM) superfamily
- transcription regulator
- RNA recognition motif
- protein binding
- poly-U binding splicing factor, half-pint family
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CELF3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- sperm motility
- regulation of alternative nuclear mRNA splicing, via spliceosome
- positive regulation of nuclear mRNA splicing, via spliceosome
- spermatogenesis
- mRNA splice site selection
- nuclear body organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- pre-mRNA binding
- RNA binding
- mRNA binding