Celf3 Gene Summary [Mouse]
Enables 7SK snRNA binding activity. Acts upstream of or within several processes, including flagellated sperm motility; lncRNA transcription; and nuclear body organization. Located in cytoplasm and nuclear body. Is expressed in several structures, including adrenal medulla; gut; nervous system; neural retina; and nose. Orthologous to human CELF3 (CUGBP Elav-like family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Celf3 |
| Official Name | CUGBP, Elav-like family member 3 [Source:MGI Symbol;Acc:MGI:1926034] |
| Ensembl ID | ENSMUSG00000028137 |
| Bio databases IDs | |
| Aliases | CUGBP, Elav-like family member 3 |
| Synonyms | 4930415M08Rik, BRUNOL1, CAGH4, CUGBP Elav-like family member 3, CUGBP, Elav-like family member 3, ERDA4, ETR-1, RGD1563168, TNRC4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Celf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ELAV/HuD family splicing factor
- snRNA binding
- RNA recognition motif (RRM) superfamily
- transcription regulator
- RNA recognition motif
- protein binding
- poly-U binding splicing factor, half-pint family
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Celf3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- sperm motility
- regulation of alternative nuclear mRNA splicing, via spliceosome
- positive regulation of nuclear mRNA splicing, via spliceosome
- spermatogenesis
- mRNA splice site selection
- nuclear body organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- pre-mRNA binding
- RNA binding
- mRNA binding