SSU72 Gene Summary [Human]
Enables RNA polymerase II CTD heptapeptide repeat phosphatase activity. Involved in dephosphorylation of RNA polymerase II C-terminal domain and mRNA polyadenylation. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SSU72 |
| Official Name | SSU72 homolog, RNA polymerase II CTD phosphatase [Source:HGNC Symbol;Acc:HGNC:25016] |
| Ensembl ID | ENSG00000160075 |
| Bio databases IDs | |
| Aliases | SSU72 homolog, RNA polymerase II CTD phosphatase |
| Synonyms | 1190002E22Rik, 1500011L16Rik, 2610101M12Rik, HSPC182, PNAS-120, RGD1307854, SSU72 homolog, RNA polymerase II CTD phosphatase, Ssu72 RNA polymerase II CTD phosphatase homolog (yeast) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SSU72 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CTD phosphatase
- Ssu72-like protein
- phosphatase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SSU72 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- termination of RNA polymerase II transcription
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- mRNA cleavage and polyadenylation specificity factor complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- CTD phosphatase activity
- myosin phosphatase activity