RAD21 Gene Summary [Human]
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RAD21 |
| Official Name | RAD21 cohesin complex component [Source:HGNC Symbol;Acc:HGNC:9811] |
| Ensembl ID | ENSG00000164754 |
| Bio databases IDs | |
| Aliases | RAD21 cohesin complex component, sister chromatid cohesion 1, kleisin |
| Synonyms | CDLS4, hHR21, HR21, HRAD21, MCD1, MGS, mHR21, mKIAA0078, NXP1, Pw29, RAD21 cohesin complex component, SCC1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAD21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- double-stranded DNA binding
- Middle HEAT-repeat binding domain of Rad21/Rec8-like proteins
- nucleic acid binding
- N terminus of Rad21 / Rec8 like protein
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- Conserved region of Rad21 / Rec8 like protein
- RNA binding
Pathways
Biological processes and signaling networks where the RAD21 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast adenocarcinoma
- serous ovarian adenocarcinoma
- serous ovarian cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- Cornelia de Lange syndrome type 4
- urothelial bladder carcinoma
- transitional cell bladder cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
role in cell
- binding in
- apoptosis
- expression in
- survival
- phosphorylation in
- cell death
- formation
- growth
- mitosis
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- midbody
- cytosol
- chromosome
- nucleoplasm
- nuclear matrix
- mitotic spindle
- chromatin structures
- centromeres
- synaptonemal complexes
- chromatin
- plasma
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAD21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sister chromatid cohesion
- reciprocal meiotic recombination
- establishment of meiotic sister chromatid cohesion
- negative regulation of interleukin-1 beta production
- negative regulation of glial cell apoptotic process
- establishment of mitotic sister chromatid cohesion
- negative regulation of mitotic metaphase/anaphase transition
- DNA recombination
- chromosome segregation
- positive regulation of sister chromatid cohesion
- regulation of transcription from RNA polymerase II promoter
- double-strand break repair
- negative regulation of neuron apoptotic process
- cell division
- response to hypoxia
- protein localization to chromatin
- apoptotic process
- positive regulation of interleukin-10 production
- negative regulation of tumor necrosis factor production
- negative regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- spindle pole
- cohesin complex
- chromosome
- chromosome, centromeric region
- chromatin
- condensed nuclear chromosome
- nucleoplasm
- nucleus
- membrane
- nuclear matrix
- cytosol
- meiotic cohesin complex
- midbody
- mitotic cohesin complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- chromatin binding