HSF2BP Gene Summary [Human]
HSF2 binding protein (HSF2BP) associates with HSF2. The interaction occurs between the trimerization domain of HSF2 and the amino terminal hydrophilic region of HSF2BP that comprises two leucine zipper motifs. HSF2BP may therefore be involved in modulating HSF2 activation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HSF2BP |
| Official Name | heat shock transcription factor 2 binding protein [Source:HGNC Symbol;Acc:HGNC:5226] |
| Ensembl ID | ENSG00000160207 |
| Bio databases IDs | |
| Aliases | heat shock transcription factor 2 binding protein, heat shock factor 2 binding protein, meiotic localizer of BRCA2 |
| Synonyms | 4932437G14Rik, heat shock transcription factor 2 binding protein, MEILB2, POF19, RGD1565879 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HSF2BP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular disorder
- COVID-19
- premature ovarian failure type 19
- eosinophilic esophagitis
- chronic obstructive pulmonary disease
- coronary artery disease
regulates
- DNA endogenous promoter
- DNA promoter
- RNA polymerase II
- BRCA2
role in cell
- meiosis I
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- chromosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HSF2BP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- male meiosis I
- transcription from RNA polymerase II promoter
- female meiosis I
Cellular Component
Where in the cell the gene product is active
- cytosol
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding