INPP5J Gene Summary [Human]
Predicted to enable phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in inositol phosphate dephosphorylation; negative regulation of peptidyl-serine phosphorylation; and phosphatidylinositol dephosphorylation. Predicted to act upstream of or within negative regulation of neuron projection development. Located in cytoplasm and ruffle. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | INPP5J |
| Official Name | inositol polyphosphate-5-phosphatase J [Source:HGNC Symbol;Acc:HGNC:8956] |
| Ensembl ID | ENSG00000185133 |
| Bio databases IDs | |
| Aliases | inositol polyphosphate-5-phosphatase J |
| Synonyms | Image:4164282, inositol polyphosphate-5-phosphatase J, Inpp, INPP5, PIB5PA, PIPP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human INPP5J often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Family of unknown function (DUF5585)
- SKICH domain
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
- inositol-polyphosphate 5-phosphatase
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- phosphatase
- protein binding
- phosphoinositide 5-phosphatase
Pathways
Biological processes and signaling networks where the INPP5J gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- cervical cancer
- epithelial uterine cancer
- cervical small cell carcinoma
- extrapulmonary small cell cancer
regulates
- 1,4,5-IP3
- phosphatidylinositol
- 1,3,4,5-IP4
- actin
- inositol phosphate
- peptide
- alpha actin
role in cell
- survival
- development
- polymerization
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- ruffle
- Cytoplasm
- cell periphery
- cytosol
- membrane ruffles
- growth cone
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human INPP5J gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inositol phosphate metabolic process
- negative regulation of neuron projection development
- negative regulation of peptidyl-serine phosphorylation
- phosphatidylinositol biosynthetic process
- phosphatidylinositol dephosphorylation
Cellular Component
Where in the cell the gene product is active
- growth cone
- cytoplasm
- dendritic shaft
- ruffle
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
- phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
- SH3 domain binding
- inositol-1,4,5-trisphosphate 5-phosphatase activity
- inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
- inositol-polyphosphate 5-phosphatase activity