Hsf2bp Gene Summary [Mouse]
Involved in meiosis I and spermatogenesis. Located in chromosome. Is expressed in several structures, including genitourinary system; nervous system; sensory organ; surface ectoderm; and thymus. Used to study primary ovarian insufficiency 19. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 19. Orthologous to human HSF2BP (heat shock transcription factor 2 binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hsf2bp |
| Official Name | heat shock transcription factor 2 binding protein [Source:MGI Symbol;Acc:MGI:1921627] |
| Ensembl ID | ENSMUSG00000002076 |
| Bio databases IDs | |
| Aliases | heat shock transcription factor 2 binding protein |
| Synonyms | 4932437G14Rik, heat shock transcription factor 2 binding protein, MEILB2, POF19, RGD1565879 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hsf2bp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular disorder
- COVID-19
- premature ovarian failure type 19
- eosinophilic esophagitis
- chronic obstructive pulmonary disease
- coronary artery disease
regulates
- DNA endogenous promoter
- DNA promoter
- RNA polymerase II
- BRCA2
role in cell
- meiosis I
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- chromosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hsf2bp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- male meiosis I
- transcription from RNA polymerase II promoter
- female meiosis I
Cellular Component
Where in the cell the gene product is active
- cytosol
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding