TSHZ3 Gene Summary [Human]
This gene encodes a zinc-finger transcription factor that regulates smooth muscle cell differentiation in the developing urinary tract. Consistent with this role, mice in which this gene has been inactivated exhibit abnormal gene expression in urinary tract smooth muscle cell precursors and kidney defects including hydronephrosis. The encoded transcription factor comprises a gene silencing complex that inhibits caspase expression. Reduced expression of this gene and consequent caspase upregulation may be correlated with progression of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2016]
Details
| Type | Processed Transcript |
| Official Symbol | TSHZ3 |
| Official Name | teashirt zinc finger homeobox 3 [Source:HGNC Symbol;Acc:HGNC:30700] |
| Ensembl ID | ENSG00000121297 |
| Bio databases IDs | |
| Aliases | teashirt zinc finger homeobox 3, teashirt 3 |
| Synonyms | A630038G13Rik, KIAA1474, mKIAA1474, teashirt3, teashirt zinc finger family member 3, teashirt zinc finger homeobox 3, TSH3, Zfp537, ZNF537 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TSHZ3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- chromatin binding
- protein binding
- zinc finger domain
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- acute myeloid leukemia
- non-insulin-dependent diabetes mellitus
- breast adenocarcinoma
- pervasive developmental disorder
- tumorigenesis
- autism-like behavioral deficit
- urothelial bladder carcinoma
- transitional cell bladder cancer
- chronic obstructive pulmonary disease
role in cell
- expression in
- upregulation in
- cell death
- binding in
- differentiation
- repression in
- downregulation in
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- nucleoplasm
- growth cone
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TSHZ3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- long-term synaptic potentiation
- positive regulation of synaptic transmission, glutamatergic
- regulation of respiratory gaseous exchange by neurological system process
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- growth cone
- nucleus
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity