HCRT Gene Summary [Human]
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]
Details
| Type | Protein Coding |
| Official Symbol | HCRT |
| Official Name | hypocretin neuropeptide precursor [Source:HGNC Symbol;Acc:HGNC:4847] |
| Ensembl ID | ENSG00000161610 |
| Bio databases IDs | |
| Aliases | hypocretin neuropeptide precursor, prepro-orexin, orexin |
| Synonyms | hypocretin, Hypocretin-1, Hypocretin-2, hypocretin neuropeptide precursor, NRCLP1, Orexin, PPORX, PPOX, Prepro-orexin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HCRT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hypocretin receptor binding
- Prepro-orexin
- neuropeptide hormone
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- narcolepsy
- hyperphagia
- cataplexy
- frontotemporal dementia
- obesity
- allodynia
- narcolepsy type 1
- narcolepsy with cataplexy
- dyssomnia
role in cell
- expression in
- apoptosis
- formation in
- phosphorylation in
- growth
- cell death
- firing
- excitation
- activation
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- Cytoplasm
- cell surface
- perinuclear region
- vesicles
- granules
- synaptic vesicles
- cytoplasmic vesicles
- rough endoplasmatic reticulum
- secretory granules
- perikaryon
- axons
- axon terminals
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HCRT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of neurotransmitter secretion
- regulation of excitatory postsynaptic membrane potential
- positive regulation of calcium ion transport
- response to starvation
- synaptic transmission
- negative regulation of potassium ion transport
- phospholipase C-activating G-protein coupled receptor signaling pathway
- negative regulation of DNA replication
- protein kinase C-activating G-protein coupled receptor signaling pathway
- eating behavior
- elevation of cytosolic calcium ion concentration
- negative regulation of transmission of nerve impulse
- neuropeptide signaling pathway
- positive regulation of transmission of nerve impulse
- temperature homeostasis
- sleep
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- secretory granule
- synaptic vesicle
- rough endoplasmic reticulum
- extracellular region
Molecular Function
What the gene product does at the molecular level
- neuropeptide hormone activity
- type 2 hypocretin receptor binding
- type 1 hypocretin receptor binding