HCRTR1 Gene Summary [Human]
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]
Details
| Type | Processed Transcript |
| Official Symbol | HCRTR1 |
| Official Name | hypocretin receptor 1 [Source:HGNC Symbol;Acc:HGNC:4848] |
| Ensembl ID | ENSG00000121764 |
| Bio databases IDs | |
| Aliases | hypocretin receptor 1, orexin receptor 1 |
| Synonyms | Hctr1, hypocretin (orexin) receptor 1, hypocretin receptor 1, ORXR1, OX1R, OXR1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HCRTR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- orexin receptor
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
- immunoreceptor tyrosine switch motif
Pathways
Biological processes and signaling networks where the HCRTR1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- depressive disorder
- binge drinking
- post-traumatic stress disorder
- shift work sleep disorder
- behavioral arrest
- insomnia
- advanced solid tumor
- bipolar I disorder
- idiopathic inflammatory myopathy
role in cell
- apoptosis
- excitation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HCRTR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- positive regulation of ERK1 and ERK2 cascade
- cytosolic calcium ion homeostasis
- feeding behavior
- synaptic transmission
- cellular response to hormone stimulus
Cellular Component
Where in the cell the gene product is active
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- peptide hormone binding
- peptide binding
- orexin receptor activity