HCRTR2
HCRTR2 Gene Summary
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]
Details
| Type | Protein Coding |
| Official Symbol | HCRTR2 |
| Official Name | hypocretin receptor 2 [Source:HGNC Symbol;Acc:HGNC:4849] |
| Ensembl ID | ENSG00000137252 |
| Bio databases IDs | |
| Aliases | hypocretin receptor 2, orexin receptor 2 |
| Synonyms | hypocretin (orexin) receptor 2,hypocretin receptor 2,mOX2aR,mOX2bR,mOXR2,ORXR2,OX2aR,OX2bR,OX2R,OXR2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- neuropeptide receptor
- Orexin receptor type 2
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- orexin receptor
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
Pathways
Biological processes and signaling networks where the HCRTR2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- MRS2
- TSPAN15
- ATP13A3
- SFXN5
- HCRT
- PTPRD
- PPIA
- suvorexant
- daridorexant
- vornorexant
disease
- hypertension
- Alzheimer disease
- diabetes mellitus
- insomnia
- bipolar II disorder
- post-traumatic stress disorder
- narcolepsy type 1
- multiple sclerosis
- behavioral arrest
- diabetic nephropathy
regulated by
- tetrodotoxin
- HCRT
- orexins
- beta-estradiol
- BMAL1
- SIRT1
- nicotine
- testosterone
- daridorexant
- lemborexant
regulates
- ERK1/2
- CREB
- D-glucose
- beta arrestin
- GNAQ
- G protein s
role in cell
- phosphorylation in
- activation in
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the HCRTR2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- locomotion
- cytosolic calcium ion homeostasis
- feeding behavior
- synaptic transmission
- cellular response to hormone stimulus
- phospholipase C-activating G-protein coupled receptor signaling pathway
- circadian sleep/wake cycle process
- regulation of circadian sleep/wake cycle, wakefulness
CELLULAR COMPONENT
Where in the cell the gene product is active
- synapse
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- neuropeptide receptor activity
- peptide hormone binding
- peptide binding
- orexin receptor activity