HS3ST6 Gene Summary [Human]

Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Predicted to be involved in glycosaminoglycan biosynthetic process. Predicted to act upstream of or within blastocyst hatching. Predicted to be located in Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]

Details

Type
Protein Coding
Official Symbol
HS3ST6
Official Name
heparan sulfate-glucosamine 3-sulfotransferase 6 [Source:HGNC Symbol;Acc:HGNC:14178]
Ensembl ID
ENSG00000162040
Bio databases IDs NCBI: 64711 Ensembl: ENSG00000162040
Aliases heparan sulfate-glucosamine 3-sulfotransferase 6
Synonyms 3-OST-6, HAE8, heparan sulfate (glucosamine) 3-O-sulfotransferase 6, heparan sulfate-glucosamine 3-sulfotransferase 6, heparan sulphate (glucosamine) 3-O-sulphotransferase 6, heparan sulphate-glucosamine 3-sulphotransferase 6, HS3ST5, LOC681900
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HS3ST6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • [heparan sulfate]-glucosamine 3-sulfotransferase 1
  • Sulfotransferase domain
  • enzyme
  • Sulfotransferase family

Pathways

Biological processes and signaling networks where the HS3ST6 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
  • heparan sulfate proteoglycan
disease
  • hereditary angioedema type VIII

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Golgi membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human HS3ST6 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • heparan sulfate proteoglycan biosynthetic process, enzymatic modification
  • blastocyst hatching

Cellular Component

Where in the cell the gene product is active
  • Golgi membrane

Molecular Function

What the gene product does at the molecular level
  • [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.