ROS1 Gene Summary [Human]
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ROS1 |
| Official Name | ROS proto-oncogene 1, receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:10261] |
| Ensembl ID | ENSG00000047936 |
| Bio databases IDs | |
| Aliases | ROS proto-oncogene 1, receptor tyrosine kinase |
| Synonyms | c-ros, c-ros-1, LOC103694423, MCF3, ROS, ROS1C, Ros1 proto-oncogene, ROS proto-oncogene 1 , receptor tyrosine kinase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ROS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- protein phosphatase binding
- protein binding
- Fibronectin type 3 domain
- protein-tyrosine kinase
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- cytoplasmic domain
- FN3
- transmembrane domain
- intracellular domain
- substrate binding domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the ROS1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- advanced lung squamous cell carcinoma
- advanced large cell lung carcinoma
- advanced non-small cell lung cancer
- metastatic lung adenocarcinoma
- metastatic non-small cell lung cancer
- stage IV lung squamous cell carcinoma
- advanced non-small cell lung adenocarcinoma
- metastatic large cell lung carcinoma
- ALK rearrangement positive non-small cell lung cancer
role in cell
- proliferation
- differentiation
- growth
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- perinuclear region
- cellular membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ROS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of ERK1 and ERK2 cascade
- multicellular organismal development
- regulation of cell growth
- spermatogenesis
- cell differentiation
- transmembrane receptor protein tyrosine kinase signaling pathway
- positive regulation of kinase activity
- columnar/cuboidal epithelial cell development
- protein phosphorylation
- regulation of TOR signaling cascade
Cellular Component
Where in the cell the gene product is active
- membrane
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- protein phosphatase binding
- transmembrane receptor protein tyrosine kinase activity