HS3ST2 Gene Summary [Human]

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. This gene is expressed predominantly in brain and may play a role in the nervous system. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
HS3ST2
Official Name
heparan sulfate-glucosamine 3-sulfotransferase 2 [Source:HGNC Symbol;Acc:HGNC:5195]
Ensembl ID
ENSG00000122254
Bio databases IDs NCBI: 9956 Ensembl: ENSG00000122254
Aliases heparan sulfate-glucosamine 3-sulfotransferase 2
Synonyms 30ST2, 3OST2, 6430516N12RIK, A830061E14, A830061E14Rik, h3-OST-2, heparan sulfate (glucosamine) 3-O-sulfotransferase 2, heparan sulfate-glucosamine 3-sulfotransferase 2, heparan sulphate (glucosamine) 3-O-sulphotransferase 2, heparan sulphate-glucosamine 3-sulphotransferase 2
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HS3ST2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • sulfotransferase
  • [heparan sulfate]-glucosamine 3-sulfotransferase 1
  • Sulfotransferase domain
  • [heparan sulfate]-glucosamine 3-sulfotransferase 2
  • enzyme
  • Sulfotransferase family

Pathways

Biological processes and signaling networks where the HS3ST2 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • chronic obstructive pulmonary disease
  • androgenic alopecia
  • epileptic seizure
regulated by
  • isoproterenol
  • decitabine
  • IL1B
  • EGR3
  • propranolol
  • bucladesine
  • TCF4
  • norepinephrine
regulates
  • glycosaminoglycan
  • heparan sulfate proteoglycan

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • pH resistant lipid raft fraction
  • detergent resistant lipid raft fraction
  • cellular membrane
  • Golgi membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human HS3ST2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • heparan sulfate proteoglycan biosynthetic process, enzymatic modification
  • glycosaminoglycan biosynthetic process

Cellular Component

Where in the cell the gene product is active
  • membrane
  • Golgi membrane

Molecular Function

What the gene product does at the molecular level
  • [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
  • sulfotransferase activity
  • [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.