JMJD4 Gene Summary [Human]
Enables 2-oxoglutarate-dependent dioxygenase activity. Involved in positive regulation of translational termination and protein hydroxylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | JMJD4 |
| Official Name | jumonji domain containing 4 [Source:HGNC Symbol;Acc:HGNC:25724] |
| Ensembl ID | ENSG00000081692 |
| Bio databases IDs | |
| Aliases | jumonji domain containing 4, 2-oxoglutarate- and Fe(II)-dependent oxygenase, C4 lysyl hydroxylase |
| Synonyms | 6430559I23, jumonji domain containing 4, RGD1307186 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human JMJD4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 2-oxoglutarate:oxygen oxidoreductase
- enzyme
- protein binding
- RmlC-like cupin superfamily
- Cupin-like domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human JMJD4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translational termination
- protein hydroxylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
- sequence-specific DNA binding