SLC45A1 Gene Summary [Human]

This gene was isolated initially from a region on chromosome 1p that is frequently deleted in human neuroblastoma, although no causal relationship has since been demonstrated. The encoded protein belongs to the glycoside-pentoside-hexuronide cation symporter transporter family and may play a role in glucose uptake. [provided by RefSeq, Mar 2014]

Details

Type
Protein Coding
Official Symbol
SLC45A1
Official Name
solute carrier family 45 member 1 [Source:HGNC Symbol;Acc:HGNC:17939]
Ensembl ID
ENSG00000162426
Bio databases IDs NCBI: 50651 Ensembl: ENSG00000162426
Aliases solute carrier family 45 member 1, H+/sugar symporter
Synonyms C230078B22, DNB5, IDDNPF, PAST-A, solute carrier family 45 member 1, solute carrier family 45, member 1
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC45A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • hexose transporter
  • Major Facilitator Superfamily
  • galactose:hydrogen symporter
  • hydrogen:glucose transporter
  • transporter

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • schizophrenia
  • intellectual developmental disorder with neuropsychiatric features
  • breast carcinoma
regulated by
  • beta-estradiol
  • ACSS2
  • MirBART2
  • acetate
regulates
  • D-glucose
  • galactose

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human SLC45A1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • sucrose transport
  • galactose transport

Cellular Component

Where in the cell the gene product is active
  • membrane

Molecular Function

What the gene product does at the molecular level
  • sucrose:hydrogen symporter activity
  • galactose:hydrogen symporter activity
  • hydrogen:glucose symporter activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.