FLAD1 Gene Summary [Human]
This gene encodes the enzyme that catalyzes adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | FLAD1 |
| Official Name | flavin adenine dinucleotide synthetase 1 [Source:HGNC Symbol;Acc:HGNC:24671] |
| Ensembl ID | ENSG00000160688 |
| Bio databases IDs | |
| Aliases | flavin adenine dinucleotide synthetase 1 |
| Synonyms | A930017E24Rik, FAD1, FADS, flavin adenine dinucleotide synthetase 1, LSMFLAD, PP591 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FLAD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Probable molybdopterin binding domain
- enzyme
- protein binding
- MoCF_BD
- identical protein binding
- Adenine nucleotide alpha hydrolase (AANH) superfamily
- FMN adenylyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lipid storage myopathy due to flavin adenine dinucleotide synthetase deficiency
- myopathy with abnormal lipid metabolism
- glutaric aciduria type 2
- senile lentigo
regulates
- riboflavin
- adenine-riboflavin dinucleotide
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FLAD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- FAD biosynthetic process
- riboflavin metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- FMN adenylyltransferase activity