SLCO4C1 Gene Summary [Human]
SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed 14993604]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | SLCO4C1 |
| Official Name | solute carrier organic anion transporter family member 4C1 [Source:HGNC Symbol;Acc:HGNC:23612] |
| Ensembl ID | ENSG00000173930 |
| Bio databases IDs | |
| Aliases | solute carrier organic anion transporter family member 4C1 |
| Synonyms | 9530051F04, C330017E21RIK, OATP4C1, OATP-H, OATP-M1, oatp-R, OATPX, PRO2176, SLC21A20, solute carrier organic anion transporter family member 4C1, solute carrier organic anion transporter family, member 4C1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLCO4C1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Organic Anion Transporter Polypeptide (OATP) family
- Major Facilitator Superfamily
- sodium-independent organic anion transporter
- organic anion transporter
- KAZAL_FS
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- digoxin
- organic anion
- sitagliptin
- SLCO4C1
disease
- non-insulin-dependent diabetes mellitus
- preeclampsia
- restless legs syndrome
role in cell
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- secretory granule membrane
- specific granule membrane
- basolateral membrane
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLCO4C1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- transmembrane transport
- spermatogenesis
- sodium-independent organic anion transport
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- azurophil granule membrane
- basolateral plasma membrane
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- organic anion transmembrane transporter activity
- sodium-independent organic anion transmembrane transporter activity