SLC30A7 Gene Summary [Human]
Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A7, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | SLC30A7 |
| Official Name | solute carrier family 30 member 7 [Source:HGNC Symbol;Acc:HGNC:19306] |
| Ensembl ID | ENSG00000162695 |
| Bio databases IDs | |
| Aliases | solute carrier family 30 member 7 |
| Synonyms | 1810059J10Rik, 2610034N15Rik, 4833428C12Rik, solute carrier family 30 member 7, solute carrier family 30 (zinc transporter), member 7, ZHS, ZNT7, ZnTL2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC30A7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cation diffusion facilitator family transporter
- zinc ion transporter
- Cation efflux family
- identical protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- Ziegler-Huang syndrome
- zinc deficiency
- Joubert syndrome type 1
- multiple sclerosis
- hyperglycemia
- weight gain
- hypopigmentation
role in cell
- expression in
- phosphorylation in
- quantity
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- sarcoplasmic reticulum
- vesicles
- Golgi Apparatus
- Mitochondria
- cytoplasmic vesicles
- Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC30A7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular zinc ion homeostasis
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasm
- mitochondrion
- vesicle
- cytoplasmic vesicle
- Golgi membrane
- Golgi apparatus
- sarcoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion transmembrane transporter activity