KATNA1 Gene Summary [Human]
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | KATNA1 |
| Official Name | katanin catalytic subunit A1 [Source:HGNC Symbol;Acc:HGNC:6216] |
| Ensembl ID | ENSG00000186625 |
| Bio databases IDs | |
| Aliases | katanin catalytic subunit A1 |
| Synonyms | AC156391.3, katanin catalytic subunit A1, katanin p60 (ATPase-containing) subunit A1, P60-katanin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KATNA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATP-binding domain
- ATP binding
- enzyme
- protein binding
- AAA+ lid domain
- ATPase
- microtubule-severing ATPase
- microtubule binding
- AAA domain (dynein-related subfamily)
- ATPase family associated with various cellular activities (AAA)
- binding protein
- ubiquitin-protein transferase activity
- GTP binding motif, P-loop
- protein heterodimerization
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung carcinoma
- lung carcinoma process
regulates
- KATNA1
- Gamma tubulin
role in cell
- migration
- outgrowth
- formation
- quantity
- development
- severing
- breakage
- length
- disassembly
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- spindle apparatus
- pericentrosomal region
- Nucleus
- Plasma Membrane
- centrosome
- midbody
- lipid droplets
- spindle pole
- growth cone
- cellular protrusions
- mitotic spindle
- perikaryon
- axons
- dendrites
- axon terminals
- sensory axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KATNA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- microtubule severing
- cytoplasmic microtubule organization
Cellular Component
Where in the cell the gene product is active
- centrosome
- microtubule cytoskeleton
- cytoplasm
- katanin complex
- spindle pole
- spindle
- midbody
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- protein heterodimerization activity
- microtubule-severing ATPase activity
- microtubule binding
- isomerase activity