ADORA2B Gene Summary [Human]
This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ADORA2B |
| Official Name | adenosine A2b receptor [Source:HGNC Symbol;Acc:HGNC:264] |
| Ensembl ID | ENSG00000170425 |
| Bio databases IDs | |
| Aliases | adenosine A2b receptor |
| Synonyms | A2b, A2B ADENOSINE receptor, A2BAR, A2BR, AA2BR, Ad2b, adenosine A2B receptor, ADORA2, ARA2B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADORA2B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- intracellular loop
- G-protein coupled adenosine receptor
- transmembrane domain
- intracellular domain
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the ADORA2B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- fibrosis
- headache
- pain
- congestion
- cough
- coronary disease
- coronary artery disease
- hypertension
- diabetes mellitus
role in cell
- migration
- quantity
- expression in
- phosphorylation in
- growth
- proliferation
- production in
- survival
- activation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- Extracellular Space
- cellular membrane
- apical cell surfaces
- basolateral cell surfaces
- apical membrane
- basolateral membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADORA2B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of mast cell degranulation
- cGMP-mediated signaling
- G-protein coupled receptor signaling pathway
- relaxation of vascular smooth muscle
- vasodilation
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- mast cell degranulation
- positive regulation of chronic inflammatory response to non-antigenic stimulus
- adenosine receptor signaling pathway
- positive regulation of cGMP-mediated signaling
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- activation of adenylate cyclase activity
- positive regulation vascular endothelial growth factor production
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- G-protein coupled adenosine receptor activity