KIF26B Gene Summary [Human]
The protein encoded by this gene is an intracellular motor protein thought to transport organelles along microtubules. The encoded protein is required for kidney development. Elevated levels of this protein have been found in some breast and colorectal cancers. [provided by RefSeq, Mar 2017]
Details
| Type | Protein Coding |
| Official Symbol | KIF26B |
| Official Name | kinesin family member 26B [Source:HGNC Symbol;Acc:HGNC:25484] |
| Ensembl ID | ENSG00000162849 |
| Bio databases IDs | |
| Aliases | kinesin family member 26B |
| Synonyms | 4832420M10, D230039L06, D230039L06Rik, FLJ10157, kinesin family member 26B, MGC35030, RGD1560022, RGD1560572 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KIF26B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kinesin motor, catalytic domain
- microtubule binding
- Myosin and Kinesin motor domain
- Kinesin motor domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- insomnia
- familial adenomatous polyposis
- schizophrenia
- migraines
- HER2 negative hormone receptor negative breast cancer
- venous thromboembolism
- osteoarthritis
- ischemic cardiomyopathy
- diverticular disease
role in cell
- expression in
- migration
- mislocalization
- polarization
- gel contraction by
- enrichment in
- mislocalization in
- accumulation
- destabilization in
- destabilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KIF26B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell-cell adhesion
- establishment of cell polarity
- microtubule-based movement
- ureteric bud invasion
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATP binding
- microtubule motor activity
- microtubule binding