EIF4E3 Gene Summary [Human]
EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004 [PubMed 15153109]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | EIF4E3 |
| Official Name | eukaryotic translation initiation factor 4E family member 3 [Source:HGNC Symbol;Acc:HGNC:31837] |
| Ensembl ID | ENSG00000163412 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 4E family member 3 |
| Synonyms | 1300018P11Rik, eukaryotic translation initiation factor 4E family member 3, eukaryotic translation initiation factor 4E member 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EIF4E3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Eukaryotic initiation factor 4E
- protein binding
- translation regulator
Pathways
Biological processes and signaling networks where the EIF4E3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- COVID-19
- backache
- plasma cell neoplasm
- B cell cancer
- mature B-cell neoplasia
- silicosis
- restless legs syndrome
- insomnia
role in cell
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EIF4E3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- translational initiation
Cellular Component
Where in the cell the gene product is active
- eukaryotic translation initiation factor 4F complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- RNA 7-methylguanosine cap binding