Eif4e3 Gene Summary [Mouse]
Predicted to enable RNA 7-methylguanosine cap binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in blood vessel; central nervous system; and sensory organ. Orthologous to human EIF4E3 (eukaryotic translation initiation factor 4E family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eif4e3 |
| Official Name | eukaryotic translation initiation factor 4E member 3 [Source:MGI Symbol;Acc:MGI:1914142] |
| Ensembl ID | ENSMUSG00000093661 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 4E member 3 |
| Synonyms | 1300018P11Rik, eukaryotic translation initiation factor 4E family member 3, eukaryotic translation initiation factor 4E member 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eif4e3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Eukaryotic initiation factor 4E
- protein binding
- translation regulator
Pathways
Biological processes and signaling networks where the Eif4e3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- COVID-19
- backache
- plasma cell neoplasm
- B cell cancer
- mature B-cell neoplasia
- silicosis
- restless legs syndrome
- insomnia
role in cell
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eif4e3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- translational initiation
Cellular Component
Where in the cell the gene product is active
- eukaryotic translation initiation factor 4F complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- RNA 7-methylguanosine cap binding