PDCD4 Gene Summary [Human]
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | PDCD4 |
| Official Name | programmed cell death 4 [Source:HGNC Symbol;Acc:HGNC:8763] |
| Ensembl ID | ENSG00000150593 |
| Bio databases IDs | |
| Aliases | programmed cell death 4, nuclear antigen H731 |
| Synonyms | 197/15A, D19Ucla1, Dug, H731, Ma3, programmed cell death 4, Tis, Topoisomerase-inhibitor suppressed |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDCD4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MA3 domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- papillomatosis
- epithelial neoplasia
- benign neoplasia
- neoplasia
- non-insulin-dependent diabetes mellitus
- myocardial infarction
- experimental autoimmune encephalomyelitis
- epithelial cancer
- cancer
- tumorigenesis
role in cell
- expression in
- growth
- apoptosis
- cell viability
- proliferation
- activation in
- differentiation
- migration
- invasion
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDCD4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of JUN kinase activity
- positive regulation of inflammatory response
- negative regulation of cytokine production involved in inflammatory response
- response to alkaloid
- response to hormone stimulus
- epithelial to mesenchymal transition involved in cardiac fibroblast development
- negative regulation of transcription, DNA-dependent
- cellular response to lipopolysaccharide
- BMP signaling pathway
- negative regulation of apoptotic process
- apoptotic process
- positive regulation of endothelial cell apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding