MNDA Gene Summary [Human]
The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | MNDA |
| Official Name | myeloid cell nuclear differentiation antigen [Source:HGNC Symbol;Acc:HGNC:7183] |
| Ensembl ID | ENSG00000163563 |
| Bio databases IDs | |
| Aliases | myeloid cell nuclear differentiation antigen |
| Synonyms | Ifi204, MYELOID AG, myeloid cell nuclear differentiation antigen, PYHIN3, rHin-3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MNDA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- PAAD/DAPIN/Pyrin domain
- double-stranded DNA binding
- transcription cofactor
- protein binding
- HIN-200/IF120x domain
- Death Domain Superfamily of protein-protein interaction domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- diabetes mellitus
- early missed abortion
- diabetic peripheral neuropathy
- severe acute respiratory syndrome
- primary biliary cirrhosis
- endometriosis
- systemic sclerosis
- COVID-19
role in cell
- expression in
- proliferation
- apoptosis
- transactivation in
- replication in
- response
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- ficolin-1-rich granule lumen
- azurophil granule lumen
- Cytoplasm
- Extracellular Space
- cytosol
- nucleoplasm
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MNDA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular defense response
- negative regulation of B cell proliferation
- activation of innate immune response
- positive regulation of apoptotic process
- response to DNA damage stimulus
- cellular response to interferon-beta
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- cytosol
- nucleolus
- extracellular region
- azurophil granule lumen
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- double-stranded DNA binding