METTL1 Gene Summary [Human]
This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | METTL1 |
| Official Name | methyltransferase like 1 [Source:HGNC Symbol;Acc:HGNC:7030] |
| Ensembl ID | ENSG00000037897 |
| Bio databases IDs | |
| Aliases | methyltransferase like 1, methyltransferase 1, tRNA methylguanosine |
| Synonyms | 2810012D02RIK, C12orf1, methyltransferase 1, tRNA methylguanosine, TRM8, TRMT8, YDL201w |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human METTL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA (guanine-N7-)-methyltransferase
- enzyme
- protein binding
- AdoMet_MTases
- mRNA methyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- neoplasia
- epithelial cancer
- liver cancer
- cognitive impairment
- hepatocellular carcinoma
- organismal death
- multiple sclerosis
- cholangiocarcinoma cancer
- acute myeloid leukemia
role in cell
- growth
- cell viability
- apoptosis
- expression in
- proliferation
- binding in
- differentiation
- quantity
- survival
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human METTL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA methylation
- tRNA modification
Cellular Component
Where in the cell the gene product is active
- tRNA methyltransferase complex
- nucleus
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- tRNA (guanine-N7-)-methyltransferase activity
- tRNA binding