IFNA4 Gene Summary [Human]
Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | IFNA4 |
| Official Name | interferon alpha 4 [Source:HGNC Symbol;Acc:HGNC:5425] |
| Ensembl ID | ENSG00000236637 |
| Bio databases IDs | |
| Aliases | interferon alpha 4 |
| Synonyms | Gm12597, Gm13280, If1ai1, If1ai10, If1ai11, If1ai12, If1ai14, If1ai2, If1ai3, If1ai4, If1ai5, If1ai6, If1ai7, If1ai8, If1ai9, Ifa1, Ifa2, Ifa5, Ifa6, Ifa7, Ifa8, Ifa9, IFN-4alpha, IFN-4α, Ifna1, Ifna11, IFN-[a]11, Ifna12, Ifna13, Ifna14, Ifna15, Ifna16, Ifna16l1, Ifna1l1, Ifna2, Ifna4l2, Ifna5, Ifna6, Ifna6T, Ifna7, Ifna8, IFNa8/6, Ifna9, Ifnaa, Ifnab, IFNalpha, IFN-alpha1, IFN alpha4, IFN-alpha4a, IFN-alpha-6, IFN-alpha-8, Ifnat6, Ifn-α, IFN-α-6, IFN-α-8, INFA4, interferon alpha 1, interferon alpha 11, interferon alpha 12, interferon alpha 13, interferon alpha 14, interferon alpha 15, interferon alpha 16, interferon, alpha 16-like 1, interferon alpha-1-like, interferon alpha 2, interferon alpha 4, interferon, alpha 4, interferon, alpha 4 like 2, interferon alpha 5, interferon, alpha 5, interferon alpha 6, interferon alpha 7, interferon alpha 9, interferon alpha B, interferon α 1, interferon α 11, interferon α 12, interferon α 13, interferon α 14, interferon α 15, interferon α 16, interferon, α 16-like 1, interferon α-1-like, interferon α 2, interferon α 4, interferon, α 4, interferon, α 4 like 2, interferon α 5, interferon, α 5, interferon α 6, interferon α 7, interferon α 9, interferon α B, LOC100912314, LOC100912356, LOC384100, MuIFN-alpha-A, MuIFN-α-A, RGD1559679, RGD1564517, RGD1565225 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IFNA4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IFab
- interferon-alpha/beta receptor binding
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the IFNA4 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Dendritic Cell Maturation
- Glucocorticoid Receptor Signaling
- IL-12 Signaling and Production in Macrophages
- IL-15 Production
- Neuroinflammation Signaling Pathway
- Retinoic acid Mediated Apoptosis Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Role of Lipids/Lipid Rafts in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- Role of PKR in Interferon Induction and Antiviral Response
- Role of RIG1-like Receptors in Antiviral Innate Immunity
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neutropenia
- neoplasia
- thrombocytopenia
- weight loss
- cytopathic effect
- acute myocarditis
- flu
- multisystem inflammatory syndrome in children
- thrombotic microangiopathy
- tumorigenesis
role in cell
- activation in
- expression in
- cell death
- apoptosis
- phosphorylation in
- differentiation
- proliferation
- activation
- growth
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IFNA4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- B cell differentiation
- positive regulation of peptidyl-serine phosphorylation of STAT protein
- B cell proliferation
- adaptive immune response
- T cell activation involved in immune response
- response to virus
- type I interferon-mediated signaling pathway
- natural killer cell activation involved in immune response
- response to exogenous dsRNA
- cytokine-mediated signaling pathway
- humoral immune response
- defense response to virus
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- interferon-alpha/beta receptor binding
- cytokine activity