CXCL3 Gene Summary [Human]
This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]
Details
| Type | Protein Coding |
| Official Symbol | CXCL3 |
| Official Name | C-X-C motif chemokine ligand 3 [Source:HGNC Symbol;Acc:HGNC:4604] |
| Ensembl ID | ENSG00000163734 |
| Bio databases IDs | |
| Aliases | C-X-C motif chemokine ligand 3 |
| Synonyms | CINC-2b, C-X-C motif chemokine ligand 3, GRO1, GRO3, GROA, GROg, GRO-gamma, Gro α, GRO-γ, MIP-2b, SCYB3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CXCL3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- cytokine
Pathways
Biological processes and signaling networks where the CXCL3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- familial hemophagocytic lymphohistiocytosis
- breast cancer
- gastric cancer
- lung adenocarcinoma
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- systemic lupus erythematosus
- colon adenocarcinoma
- colon epithelial cancer
role in cell
- migration
- growth
- response
- binding
- chemotaxis
- proliferation
- recruitment
- activation
- cell rolling
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CXCL3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- cellular response to lipopolysaccharide
- chemokine-mediated signaling pathway
- neutrophil chemotaxis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- CXCR chemokine receptor binding
- chemokine activity