TGM4 Gene Summary [Human]
Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in peptide cross-linking. Predicted to act upstream of or within mating plug formation. Located in Golgi apparatus and collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | TGM4 |
| Official Name | transglutaminase 4 [Source:HGNC Symbol;Acc:HGNC:11780] |
| Ensembl ID | ENSG00000163810 |
| Bio databases IDs | |
| Aliases | transglutaminase 4 |
| Synonyms | 9530008N10RIK, Dp1, Eapa1, hTGP, TGP, Transglutaminase 4, transglutaminase 4 (prostate) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TGM4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transglutaminase-like superfamily
- Transglutaminase/protease-like homologues
- protein-glutamine gamma-glutamyltransferase
- enzyme
- Transglutaminase family, C-terminal ig like domain
- Transglutaminase family
Pathways
Biological processes and signaling networks where the TGM4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Golgi Apparatus
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TGM4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptide cross-linking
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein-glutamine gamma-glutamyltransferase activity
- metal ion binding