TBC1D14 Gene Summary [Human]
Enables protein kinase binding activity. Involved in negative regulation of autophagy; recycling endosome to Golgi transport; and regulation of autophagosome assembly. Located in several cellular components, including Golgi apparatus; autophagosome; and recycling endosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TBC1D14 |
| Official Name | TBC1 domain family member 14 [Source:HGNC Symbol;Acc:HGNC:29246] |
| Ensembl ID | ENSG00000132405 |
| Bio databases IDs | |
| Aliases | TBC1 domain family member 14 |
| Synonyms | 2810413P16Rik, D5ERTD110E, LOC100045928, mKIAA1322, SRF-2, TBC1 domain family member 14, TBC1 domain family, member 14, UR-NR#2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TBC1D14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rab-GTPase-TBC domain
- protein kinase binding
- Domain in Tre-2, BUB2p, and Cdc16p
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- thrombocytopenia
- organismal death
- survival
- eczema
role in cell
- migration
- invasion by
- formation in
- formation
- tubulation
- autophagy by
- exocytosis by
- autophagy in
- assembly
- exocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- endosomes
- Golgi Apparatus
- nucleoplasm
- autophagic vacuoles
- recycling endosomes
- autophagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TBC1D14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of autophagy
- autophagy
- regulation of autophagic vacuole assembly
- recycling endosome to Golgi transport
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cytosol
- Golgi apparatus
- recycling endosome
- autophagic vacuole
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- GTPase activator activity