Tgm4 Gene Summary [Mouse]
Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Acts upstream of or within mating plug formation. Predicted to be located in Golgi apparatus. Predicted to be active in collagen-containing extracellular matrix. Is expressed in anterior prostate gland; prostate gland dorsolateral lobe; and ventral prostate gland. Orthologous to human TGM4 (transglutaminase 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Tgm4 |
| Official Name | transglutaminase 4 (prostate) [Source:MGI Symbol;Acc:MGI:3027002] |
| Ensembl ID | ENSMUSG00000025787 |
| Bio databases IDs | |
| Aliases | transglutaminase 4 (prostate) |
| Synonyms | 9530008N10RIK, Dp1, Eapa1, hTGP, TGP, Transglutaminase 4, transglutaminase 4 (prostate) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tgm4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transglutaminase-like superfamily
- Transglutaminase/protease-like homologues
- protein-glutamine gamma-glutamyltransferase
- enzyme
- Transglutaminase family, C-terminal ig like domain
- Transglutaminase family
Pathways
Biological processes and signaling networks where the Tgm4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- psoriasis
- essential tremor
- tinnitus
- venous thromboembolism
phenotypes
- abnormal male reproductive system physiology
- failure of copulatory plug formation
- impaired fertilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Golgi Apparatus
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tgm4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptide cross-linking
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein-glutamine gamma-glutamyltransferase activity
- metal ion binding