MELTF Gene Summary [Human]
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | MELTF |
| Official Name | melanotransferrin [Source:HGNC Symbol;Acc:HGNC:7037] |
| Ensembl ID | ENSG00000163975 |
| Bio databases IDs | |
| Aliases | melanotransferrin, membrane-bound transferrin-like protein |
| Synonyms | CD228, Magea1, MAP97, melanotransferrin, MFI2, MTF, MTF1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MELTF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Type 2 periplasmic binding fold superfamily
- iron ion binding
- protein binding
- Transferrin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- osteosarcoma
- osteosarcomagenesis
- melanoma
- melanoma cancer
- alveolar soft part sarcoma
- soft tissue sarcoma cancer
regulates
- iron ion
- doxorubicin
- PLG
role in cell
- migration
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- endoplasmic reticulum lumen
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MELTF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of extracellular matrix disassembly
- regulation of cell growth
- iron ion transport
- negative regulation of substrate adhesion-dependent cell spreading
- positive regulation of plasminogen activation
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- early endosome
- extracellular vesicular exosome
- recycling endosome
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- iron ion binding