Meltf Gene Summary [Rat]
Predicted to enable iron ion binding activity. Predicted to be involved in several processes, including negative regulation of substrate adhesion-dependent cell spreading; positive regulation of extracellular matrix disassembly; and positive regulation of plasminogen activation. Predicted to be located in cell surface. Predicted to be active in endosome; extracellular space; and plasma membrane. Orthologous to human MELTF (melanotransferrin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Meltf |
| Official Name | melanotransferrin [Source:RGD Symbol;Acc:1308155] |
| Ensembl ID | ENSRNOG00000001739 |
| Bio databases IDs | |
| Aliases | melanotransferrin |
| Synonyms | CD228, Magea1, MAP97, melanotransferrin, MFI2, MTF, MTF1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Meltf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Type 2 periplasmic binding fold superfamily
- iron ion binding
- protein binding
- Transferrin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- osteosarcoma
- osteosarcomagenesis
- melanoma
- melanoma cancer
- alveolar soft part sarcoma
- soft tissue sarcoma cancer
regulates
- iron ion
- doxorubicin
- PLG
role in cell
- migration
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- endoplasmic reticulum lumen
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Meltf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of extracellular matrix disassembly
- regulation of cell growth
- iron ion transport
- negative regulation of substrate adhesion-dependent cell spreading
- positive regulation of plasminogen activation
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- early endosome
- extracellular vesicular exosome
- recycling endosome
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- iron ion binding