TRMT2A Gene Summary [Human]

The protein encoded by this gene is of unknown function. However, it is orthologous to the mouse Trmt2a gene and contains an RNA methyltransferase domain. Expression of this gene varies during the cell cycle, with aberrant expression being a possible biomarker in certain breast cancers. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Details

Type
Protein Coding
Official Symbol
TRMT2A
Official Name
tRNA methyltransferase 2 homolog A [Source:HGNC Symbol;Acc:HGNC:24974]
Ensembl ID
ENSG00000099899
Bio databases IDs NCBI: 27037 Ensembl: ENSG00000099899
Aliases tRNA methyltransferase 2 homolog A, HpaII tiny fragments locus 9C
Synonyms HTF9C, TRM2 tRNA methyltransferase 2A, tRNA methyltransferase 2 homolog A
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRMT2A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • kinase
  • RNA recognition motif (RRM) superfamily
  • S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase
  • RNA recognition motif
  • 23S rRNA (uracil-5-)-methyltransferase RumA
  • protein binding
  • C-methyltransferase
  • methyltransferase domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cytosol

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human TRMT2A gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • tRNA processing
  • mRNA processing
  • methylation

Cellular Component

Where in the cell the gene product is active
  • cytosol

Molecular Function

What the gene product does at the molecular level
  • RNA binding
  • protein binding
  • C-methyltransferase activity
  • S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.