MAP9 Gene Summary [Human]
ASAP is a microtubule-associated protein required for spindle function, mitotic progression, and cytokinesis (Saffin et al., 2005 [PubMed 16049101]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | MAP9 |
| Official Name | microtubule associated protein 9 [Source:HGNC Symbol;Acc:HGNC:26118] |
| Ensembl ID | ENSG00000164114 |
| Bio databases IDs | |
| Aliases | microtubule associated protein 9, aster-associated protein |
| Synonyms | 5033421J10RIK, 5330427D05Rik, ASAP, FLJ21159, microtubule-associated protein 9, Mtap9, RGD1560368 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- Coiled-coil domain-containing protein 3
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Burkitt lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- tumorigenesis
- organismal death
- chromosomal instability
- familial adenomatous polyposis
regulates
- agar
role in cell
- growth
- invasion by
- depolarization
- abnormal morphology
- aneuploidy
- assembly
- aneuploidization
- bundling
- organization
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- basal bodies
- asters
- astral microtubules
- central spindle
- mitotic spindle
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAP9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytokinesis after mitosis
- regulation of mitotic spindle organization
- regulation of mitotic centrosome separation
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- spindle midzone
- mitotic spindle
- cytoplasm
- astral microtubule
- axon
Molecular Function
What the gene product does at the molecular level
- microtubule binding