SH3KBP1
SH3KBP1 Gene Summary
This gene encodes an adapter protein that contains one or more N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
Details
| Type | Protein Coding |
| Official Symbol | SH3KBP1 |
| Official Name | SH3 domain containing kinase binding protein 1 [Source:HGNC Symbol;Acc:HGNC:13867] |
| Ensembl ID | ENSG00000147010 |
| Bio databases IDs | |
| Aliases | SH3 domain containing kinase binding protein 1 |
| Synonyms | 1200007H22Rik,1700125L08Rik,5830464D22Rik,AGMX2,AI447724,CD2BP3,CIN85,GIG10,HSB-1,IMD61,IN85,MIG18,RUK,Seta,SH3 domain-containing kinase-binding protein 1,SH3-domain kinase binding protein 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- RXXs motif
- coiled-coil domain
- protein binding
- PXXP motif
- proline rich domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the SH3KBP1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- PDGFRB
- PIK3CD
- ITSN1
- MOV10
- CSNK1A1
- PRC1
- CBLB
- PRNP
- CDC27
- CAPZA1
disease
- prostate cancer
- immunodeficiency type 61
- infiltrating ductal breast carcinoma
- invasive ductal breast cancer
- androgenic alopecia
regulated by
- PLN
- PRKAG3
- FCGR2A
- TCR (complex)
- MET
- EGF
- CD5
- SH3KBP1
- RELA
- FcER1
regulates
- ERK1/2
- FN1
- HIF1A
- CDH1
- MYC
- ZFP36
- SNAI1
- dopamine
- XBP1
- ITSN1
role in cell
- binding in
- proliferation
- survival
- migration
- expression in
- cell death
- apoptosis
- phosphorylation in
- accumulation in
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- cellular membrane
- Plasma Membrane
- endosomes
- intercellular junctions
- cytosol
- perinuclear space
- synaptosomes
- synapse
- late endosomes
- endocytotic vesicle
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the SH3KBP1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of cell shape
- positive regulation of B cell activation
- cytoskeleton organization
- apoptotic process
- cell-cell signaling
- actin filament organization
- endocytosis
- cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- endocytic vesicle
- cytoplasmic vesicle membrane
- cytoskeleton
- cell-cell junction
- focal adhesion
- cytoplasm
- cytosol
- synapse
- neuron projection
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding
- SH3 domain binding