NDC80 Gene Summary [Human]
This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | NDC80 |
| Official Name | NDC80 kinetochore complex component [Source:HGNC Symbol;Acc:HGNC:16909] |
| Ensembl ID | ENSG00000080986 |
| Bio databases IDs | |
| Aliases | NDC80 kinetochore complex component |
| Synonyms | 2610020P18Rik, HEC, HEC1, HsHec1, hsNDC80, Kinetochore associated 2, KNTC2, NDC80 kinetochore complex component, TID3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NDC80 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF5595)
- microtubule binding
- HEC/Ndc80p family
- protein binding activity, bridging
- coiled-coil domain
- protein binding
- identical protein binding
- cyclin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- epithelial neoplasia
- lung squamous cell carcinoma
- non-small cell lung cancer
- small cell lung cancer
- gastric adenocarcinoma
- breast carcinoma
- head and neck squamous cell carcinoma
role in cell
- binding in
- formation
- cell viability
- apoptosis
- segregation
- checkpoint control
- oscillation
- survival
- mitosis
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- centrosome
- cytosol
- chromosome
- nucleoplasm
- nuclear speckles
- kinetochores
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NDC80 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- positive regulation of mitotic cell cycle spindle assembly checkpoint
- mitotic spindle organization
- chromosome segregation
- spindle assembly involved in female meiosis I
- mitotic cell cycle
- meiotic G2/MI transition
- cell division
- establishment of mitotic spindle orientation
- metaphase plate congression
- regulation of protein stability
- centrosome duplication
- kinetochore organization
- attachment of spindle microtubules to kinetochore
- mitotic sister chromatid segregation
- satellite cell proliferation
- attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- Ndc80 complex
- membrane
- cytosol
- kinetochore
- condensed chromosome outer kinetochore
- chromosome, centromeric region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- cyclin binding
- microtubule binding