NPY1R Gene Summary [Human]
This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | NPY1R |
| Official Name | neuropeptide Y receptor Y1 [Source:HGNC Symbol;Acc:HGNC:7956] |
| Ensembl ID | ENSG00000164128 |
| Bio databases IDs | |
| Aliases | neuropeptide Y receptor Y1 |
| Synonyms | neuropeptide Y receptor Y1, NPY-1, NPYIR, NPYR, NPY receptor Y1, Y1-R, Y1 receptor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NPY1R often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- peptide YY receptor
- pancreatic polypeptide receptor
- Cholecystokinin A receptor, N-terminal
- neuropeptide Y receptor
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the NPY1R gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- cardiac fibrosis
- breast carcinoma
- gastric epithelial cancer
- hyperactive behavior
- obesity
- ischemic stroke
- delayed hypersensitive reaction
role in cell
- production in
- activation
- survival
- proliferation
- quantity
- function
- maturation
- number
- differentiation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- cell surface
- cellular membrane
- presynaptic membrane
- synaptic vesicles
- secretory granules
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NPY1R gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- neuropeptide signaling pathway
- regulation of multicellular organism growth
- locomotory behavior
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- outflow tract morphogenesis
- sensory perception of pain
- feeding behavior
- glucose metabolic process
- regulation of blood pressure
Cellular Component
Where in the cell the gene product is active
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- neuropeptide binding
- protein binding
- peptide YY receptor activity
- neuropeptide receptor activity
- pancreatic polypeptide receptor activity
- neuropeptide Y receptor activity