PGGT1B Gene Summary [Human]
Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]
Details
| Type | Protein Coding |
| Official Symbol | PGGT1B |
| Official Name | protein geranylgeranyltransferase type I subunit beta [Source:HGNC Symbol;Acc:HGNC:8895] |
| Ensembl ID | ENSG00000164219 |
| Bio databases IDs | |
| Aliases | protein geranylgeranyltransferase type I subunit beta |
| Synonyms | 2010207C17Rik, 2610100E13, AI551093, BGG1, BGGI, GGT1, GGT-1-beta, GGT-1-β, GGTase1 β, Ggtase-i, GGTI, PGGTB1, protein geranylgeranyltransferase type I, beta subunit, protein geranylgeranyltransferase type I subunit beta, protein geranylgeranyltransferase type I subunit β, protein geranylgeranyltransferase type I, β subunit |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PGGT1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prenyltransferase and squalene oxidase repeat
- ISOPREN_C2_like
- peptide binding
- binding protein
- CAAX-protein geranylgeranyltransferase
- zinc ion binding
- protein geranylgeranyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- epithelial cancer
- epithelial neoplasia
- myeloproliferative disorder
role in cell
- proliferation
- survival
- number
- migration
- morphology
- abnormal morphology
- modification in
- cell cycle progression
- disruption
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PGGT1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein geranylgeranylation
Cellular Component
Where in the cell the gene product is active
- CAAX-protein geranylgeranyltransferase complex
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- protein geranylgeranyltransferase activity
- CAAX-protein geranylgeranyltransferase activity