MIEN1 Gene Summary [Human]
Involved in negative regulation of apoptotic process; positive regulation of cell migration; and positive regulation of filopodium assembly. Located in several cellular components, including centriolar satellite; cytosol; and nucleoplasm. Is intrinsic component of the cytoplasmic side of the plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | MIEN1 |
| Official Name | migration and invasion enhancer 1 [Source:HGNC Symbol;Acc:HGNC:28230] |
| Ensembl ID | ENSG00000141741 |
| Bio databases IDs | |
| Aliases | migration and invasion enhancer 1 |
| Synonyms | 1810046J19Rik, C17orf37, C35, LOC102552549, migration and invasion enhancer 1, ORB3, RDX12, RGD1306682, XTP4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MIEN1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CAAX box
- Rdx family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- inner membrane
- Plasma Membrane
- Mitochondria
- cytosol
- cytoplasmic face of plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MIEN1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- apoptotic process
- positive regulation of filopodium assembly
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding