Pggt1b Gene Summary [Rat]
Enables heterocyclic compound binding activity. Contributes to CAAX-protein geranylgeranyltransferase activity; peptide binding activity; and zinc ion binding activity. Involved in positive regulation of cell cycle; positive regulation of cell population proliferation; and protein geranylgeranylation. Part of CAAX-protein geranylgeranyltransferase complex. Orthologous to human PGGT1B (protein geranylgeranyltransferase type I subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pggt1b |
| Official Name | protein geranylgeranyltransferase type I subunit beta [Source:RGD Symbol;Acc:621754] |
| Ensembl ID | ENSRNOG00000003541 |
| Bio databases IDs | |
| Aliases | protein geranylgeranyltransferase type I subunit beta |
| Synonyms | 2010207C17Rik, 2610100E13, AI551093, BGG1, BGGI, GGT1, GGT-1-beta, GGT-1-β, GGTase1 β, Ggtase-i, GGTI, PGGTB1, protein geranylgeranyltransferase type I, beta subunit, protein geranylgeranyltransferase type I subunit beta, protein geranylgeranyltransferase type I subunit β, protein geranylgeranyltransferase type I, β subunit |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pggt1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prenyltransferase and squalene oxidase repeat
- ISOPREN_C2_like
- peptide binding
- binding protein
- CAAX-protein geranylgeranyltransferase
- zinc ion binding
- protein geranylgeranyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- epithelial cancer
- epithelial neoplasia
- myeloproliferative disorder
role in cell
- proliferation
- survival
- number
- migration
- morphology
- abnormal morphology
- modification in
- cell cycle progression
- disruption
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pggt1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein geranylgeranylation
Cellular Component
Where in the cell the gene product is active
- CAAX-protein geranylgeranyltransferase complex
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- protein geranylgeranyltransferase activity
- CAAX-protein geranylgeranyltransferase activity