CMBL Gene Summary [Human]
CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 [PubMed 20177059]).[supplied by OMIM, Apr 2010]
Details
| Type | Processed Transcript |
| Official Symbol | CMBL |
| Official Name | carboxymethylenebutenolidase homolog [Source:HGNC Symbol;Acc:HGNC:25090] |
| Ensembl ID | ENSG00000164237 |
| Bio databases IDs | |
| Aliases | carboxymethylenebutenolidase homolog |
| Synonyms | 2310016A09Rik, carboxymethylenebutenolidase homolog, JS-1, LOC134147, RGD1306952 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CMBL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dienelactone hydrolase family
- alpha/beta hydrolases
- enzyme
- hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CMBL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- xenobiotic metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- hydrolase activity