CHST7 Gene Summary
This gene is a member of the Gal/GalNAc/GlcNAc (galactose/N-acetylgalactosamine/N-acetylglucosamine) 6-O-sulfotransferase (GST) family. Members of this family encode enzymes that catalyze the specific addition of sulfate groups to distinct hydroxyl and amino groups of carbohydrates. The encoded protein catalyzes the sulfation of 6-hydroxyl group of GalNAc in chondroitin. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | CHST7 |
| Official Name | carbohydrate sulfotransferase 7 [Source:HGNC Symbol;Acc:HGNC:13817] |
| Ensembl ID | ENSG00000147119 |
| Bio databases IDs | |
| Aliases | carbohydrate sulfotransferase 7 |
| Synonyms | 2600013M07Rik,C6ST-2,carbohydrate sulfotransferase 7,carbohydrate sulphotransferase 7,glcNAc6ST-4,Gn6st-4,GST-5 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sulfotransferase
- chondroitin 6-sulfotransferase
- N-acetylglucosamine-6-O-sulfotransferase
- enzyme
Pathways
Biological processes and signaling networks where the CHST7 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Crohn disease
- diabetic nephropathy
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
regulates
- benzyl 2-acetamido-2-deoxy-beta-d-glucopyranoside
- Glycam1
- IgG
- chondroitin
- N-acetylglucosamine
- keratan sulfate
- polysaccharide
- N-acetylglucosamine beta1-O-(CH2)7-CH3
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CHST7 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- chondroitin sulfate biosynthetic process
- polysaccharide metabolic process
- sulfur compound metabolic process
- N-acetylglucosamine metabolic process
cellular COMPONENT
Where in the cell the gene product is active
- trans-Golgi network
- membrane
- Golgi membrane
molecular FUNCTION
What the gene product does at the molecular level
- N-acetylglucosamine 6-O-sulfotransferase activity
- chondroitin 6-sulfotransferase activity