CALML3 Gene Summary [Human]
Predicted to enable calcium ion binding activity and enzyme regulator activity. Predicted to be involved in regulation of catalytic activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CALML3 |
| Official Name | calmodulin like 3 [Source:HGNC Symbol;Acc:HGNC:1452] |
| Ensembl ID | ENSG00000178363 |
| Bio databases IDs | |
| Aliases | calmodulin like 3 |
| Synonyms | 2310068O22RIK, calmodulin-like 3, CLP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CALML3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- EF-hand domain
- EF-hand domain pair
- EF hand
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- calcium ion binding
- EFh
- protein binding
- Ca2+ insensitive EF hand
- EFh_MICU
- EFh_PI-PLC
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- lichen planus
regulates
- 18:0/16:1 phosphatidylserine
- 18:0/20:3 phosphatidylserine
- 18:1/18:1 phosphatidylserine
- 18:1/22:0 phosphatidylserine
- phosphatidylserine
- MYO10
role in cell
- migration
- proliferation
- morphology
- quantity
- synthesis in
- oxidative phosphorylation in
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- Nucleus
- Mitochondria
- synaptic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CALML3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of ryanodine-sensitive calcium-release channel activity
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding