GKAP1 Gene Summary [Human]
This gene encodes a protein that is highly similar to the mouse cGMP-dependent protein kinase anchoring protein 42kDa. The mouse protein has been found to localize with the Golgi and recruit cGMP-dependent protein kinase I alpha to the Golgi in mouse testes. It is thought to play a role in germ cell development. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Details
| Type | Protein Coding |
| Official Symbol | GKAP1 |
| Official Name | G kinase anchoring protein 1 [Source:HGNC Symbol;Acc:HGNC:17496] |
| Ensembl ID | ENSG00000165113 |
| Bio databases IDs | |
| Aliases | G kinase anchoring protein 1, cGMP-dependent protein kinase anchoring protein 42kDa |
| Synonyms | 4933400B15Rik, D13Ertd340e, FKSG21, GKAP42, G kinase anchoring protein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GKAP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil domain
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GKAP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of insulin receptor signaling pathway
- signal transduction
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding