PRKG1 Gene Summary [Human]
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | PRKG1 |
| Official Name | protein kinase cGMP-dependent 1 [Source:HGNC Symbol;Acc:HGNC:9414] |
| Ensembl ID | ENSG00000185532 |
| Bio databases IDs | |
| Aliases | protein kinase cGMP-dependent 1 |
| Synonyms | AAT8, cGK, cGK 1, CGKI, CGKI β, Cgmp-dependent protein kinase, alpha, Cgmp-dependent protein kinase, α, CYCLIC GMP-DEPENDENT protein KINASE, Gm19690, LOC100503436, LOC100912084, PKG, PKG1, PKGI, PKGI-alpha, PKGI-α, PRKG1B, Prkg1 mapped, PRKGR1B, protein kinase cGMP-dependent 1, protein kinase, cGMP-dependent, type I |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRKG1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cGMP-dependent protein kinase
- protein serine/threonine kinase
- protein kinase
- regulatory domain
- leucine zipper domain
- Protein kinase domain
- identical protein binding
- Tyrosine kinase, catalytic domain
- Protein kinase (unclassified specificity)
- dimerization domain
- autoinhibitory protein domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- mitogen-activated protein kinase p38 binding
- nuclear localization sequence
- protein binding
- Cyclic nucleotide-monophosphate binding domain
- calcium channel regulator
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Cyclic nucleotide-binding domain
- Protein Kinases, catalytic domain
- Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
- 3',5'-cGMP binding
- CAP_ED
Pathways
Biological processes and signaling networks where the PRKG1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Cellular Effects of Sildenafil (Viagra)
- Circadian Rhythm Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- eNOS Signaling
- Ephrin A Signaling
- Gap Junction Signaling
- Netrin Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- Sertoli Cell-Sertoli Cell Junction Signaling
- Sperm Motility
- Synaptic Long Term Depression
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- diverticular disease
- epithelial cancer
- stroke
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- migraines
- laryngeal carcinoma
- laryngeal cancer
- cleft lip
role in cell
- cell death
- phosphorylation in
- expression in
- size
- production in
- apoptosis
- number
- proliferation
- quantity
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nociceptive collateral
- cell periphery
- perinuclear region
- Plasma Membrane
- Golgi Apparatus
- cell-cell contacts
- cytosol
- primary cilia
- nucleoplasm
- acrosome
- growth cone
- neurites
- sarcolemma
- actin stress fibers
- filopodia
- perikaryon
- axons
- plasma
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRKG1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cGMP-mediated signaling
- spermatid development
- cerebellum development
- signal transduction
- negative regulation of platelet aggregation
- relaxation of vascular smooth muscle
- collateral sprouting
- negative regulation of glutamate secretion
- protein phosphorylation
- cell growth involved in cardiac muscle cell development
- positive regulation of circadian rhythm
- elevation of cytosolic calcium ion concentration
- neuron migration
- forebrain development
- protein kinase A signaling cascade
- regulation of GTPase activity
- negative regulation of inositol phosphate biosynthetic process
- actin cytoskeleton organization
- dendrite development
- regulation of testosterone biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- acrosomal vesicle
- sarcolemma
- cytosol
- Golgi apparatus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- mitogen-activated protein kinase p38 binding
- cGMP-dependent protein kinase activity
- protein kinase activity
- calcium channel regulator activity
- cGMP binding