AVPR1A Gene Summary [Human]
The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | AVPR1A |
| Official Name | arginine vasopressin receptor 1A [Source:HGNC Symbol;Acc:HGNC:895] |
| Ensembl ID | ENSG00000166148 |
| Bio databases IDs | |
| Aliases | arginine vasopressin receptor 1A |
| Synonyms | arginine vasopressin receptor 1A, AVPR, AVPR1, AVPR V1a, ax55781, V1a, V1aR, Vpr1a |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AVPR1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- intracellular loop
- Cholecystokinin A receptor, N-terminal
- vasopressin receptor
- protein kinase C binding
- G-protein-coupled receptor binding
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
- transmembrane domain
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- Vasopressin V1 receptor, C-terminal
Pathways
Biological processes and signaling networks where the AVPR1A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- septic shock
- sepsis
- shock response
- epithelial cancer
- obesity
- liver cancer
- bleeding
- cardiac arrest
- diabetes insipidus
- aldosterone producing adrenocortical adenoma
role in cell
- expression in
- differentiation
- activation
- proliferation
- growth
- formation
- number
- osteoblastogenesis
- resorption by
- elevation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- caveolae fraction
- membrane fraction
- cell surface
- cellular membrane
- endosomes
- Endoplasmic Reticulum
- cytoplasmic vesicles
- endocytotic vesicle
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AVPR1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of heart rate
- sperm ejaculation
- telencephalon development
- positive regulation of vasoconstriction
- positive regulation of cell proliferation
- cellular response to water deprivation
- maternal behavior
- regulation of systemic arterial blood pressure by vasopressin
- positive regulation of cell growth
- grooming behavior
- positive regulation of cellular pH reduction
- calcium-mediated signaling
- social behavior
- generation of precursor metabolites and energy
- G-protein coupled receptor signaling pathway
- positive regulation of prostaglandin biosynthetic process
- positive regulation of systemic arterial blood pressure
- blood circulation
- negative regulation of female receptivity
- elevation of cytosolic calcium ion concentration
- maternal aggressive behavior
- response to corticosterone stimulus
- negative regulation of transmission of nerve impulse
- myotube differentiation
- cellular response to hormone stimulus
- positive regulation of glutamate secretion
Cellular Component
Where in the cell the gene product is active
- endocytic vesicle
- endosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- protein binding
- vasopressin receptor activity
- V1A vasopressin receptor binding
- peptide binding
- peptide hormone binding